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| 1563 | Philip II |  |
| William I resigns from the Dutch Council of State over Philip's Hispanicization |
| 1564 | Philip II | |
| Madrid Accepts the resignation of Graneville from the Council of State in The Netherlands |
| 1573 | Alba | |
| Oct Resigns as Viceroy of the Spanish Netherlands after several setbacks |
| 1868 | Gonzalez Bravo, Luis | |
| Madrid Forced to resign after the deposition of Queen Isabella II |
| 1874 | Castelar, Emilio | |
| 2nd Jan Madrid Castelar resigns from office |
| 1929 | Rivera, Jose Primo de | |
| 28th Jan Madrid Resignation of Jose Primo de Rivera |
| 1933 | Azana, Manuel | |
| Madrid Forced to resign due to the speed of his reforms |
| 1934 | Samper, Ricardo | |
| Oct Madrid Resigns as Prime Minister of Spain |
| 1935 | Alcala Zamora, Niceto | |
| 29th Oct Madrid Lerroux resigns, Zamora refuses to call up Gil Robles & military plotting ensues |
| 1935 | Chapaprieta, Joaquin | |
| 14th Dec The Chapaprieta government collapses |
| 1935 | Lerroux, Alejandro | |
| 29th Oct Madrid Forced to resign after the "straperlo" gambling scandal & widespread corruption |
| 1936 | Alcala Zamora, Niceto | |
| 7th April Madrid Deposed after failing to end political violence, deposed by the Cortes |
| 1936 | Franco-Bahamonde, Francisco Paulino Hermenegildo | |
| 19th July Santiago Casares Quiroga resigns as chief of the Republican government |
| 1936 | Quiroga, Santiago Casares | |
| 19th July Santiago Casares Quiroga resigns as chief of the Republican government |
| 1936 | Valladares, Manuel Portela | |
| 19th May The Valladares government collapses |
| 1937 | Largo Caballero, Francisco | |
| 17th May Barcelona Refuses demands by the communists to break up the marxist POUM & the government falls |
| 1976 | Arias Navarro, Carlos | |
| Madrid Resigns following problems making a transition to democracy |
| 1981 | Suarez, Adolfo | |
| 29th Jan Madrid Resigns in the face of right wing opposition within his party |
